Asociacion Centro De Investigacion Cooperativa En Biociencias
Jesus Jiménez Barbero:
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Nicola Abrescia:
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CIC bioGUNE, located in the Science and Technology Park of Bizkaia in Derio, Bilbao, operates in a space of 8,200 sq meters and it is the largest non-profit biomedical research organisation in the Basque region, dedicated to cutting-edge life sciences research, technology transfer, industrial and basic research, training, international collaboration, and dissemination. It focuses its scientific leadership on two strategic research areas: ‘molecular recognition and host-pathogen interactions’ and ‘metabolism and cell signalling in disease’.
The more than 200 scientists and technicians are organized into 19 research groups and 6 technology platforms focused on investigating scientific topics within these two core programs by developing more than 120 research projects annually.
In InFlaMe CIC bioGUNE has a major role considering access to state-of-the-art research infrastructure, including genomics, proteomics, metabolomics, NMR, cryoEM, X-ray facilities, AAALAC-approved animal facilities. The NMR facility is Singular Scientific & Technological Infrastructure in Spain, with 400, 600 (x3), 800, and 1000 MHz instruments.
The cryoEM facility is part of the Basque Research Technological Alliance-EM (BRTA-EM) network, which, together with the Basque Resource for Electron Microscopy (BREM) facility, houses the most powerful cryoEM instrumentation in Spain.
Prof. Jesús Jiménez Barbero
Jesús Jiménez-Barbero is an Ikerbasque Research Professor, head of the Chemical Glycobiology lab and Scientific Director of CICbioGUNE. His research focuses on Chemical Biology, specifically the molecular mechanisms of ligand recognition, particularly glycans, by biological receptors concerning cancer and infectious diseases. His lab uses a multi-faceted approach, including chemical synthesis, protein biochemistry, molecular biology, biophysics, molecular modeling, and structural biology techniques, including X-Ray crystallography and CryoEM, with special emphasis on the applications of NMR spectroscopy. His group is mainly involved in WP3 and WP5.
Prof. Nicola G.A. Abrescia
Nicola G.A. Abrescia is an Ikerbasque Research Professor and leads the Structure and Cell Biology of Viruses Lab at CIC bioGUNE. His research focuses on deciphering the molecular mechanisms of viral pathogenesis using state-of-the-art structural methods. His team investigates key areas such as virus assembly, viral cell entry, and virus-antibody recognition mechanisms. The lab employs an integrative approach combining cryo-electron microscopy, cryo-electron tomography, and cellular cryo-electron tomography, complemented by functional studies. He is a strong advocate for the democratization of cryo-EM and has played a pivotal role in advancing biological cryo-EM in the Basque Country. The Abrescia lab, as part of the InFlaMe team, leads and contributes to tasks in WP3 (Dissection of the B cell response and selection of human mAbs) and WP5 (Virus-host interactions and drug development).
